Rougier N, Verdy C, Chesne C. The inhibitive capabilities of a bacterial anti-adhesion gel on the adhesion of Propionibacterium acnes on the corneocytes of subjects with acne. Nouv Dermatol. 2003;22:7-11.


  • Test persons were exposed to a Propionibacterium acnes and treated with a 3% bacterial anti-adhesion gel. The decrease of the bacterium was measured via fluorescent reaction


  • 7 volunteers with acne-prone skin
Rougier et al Case Study Chart


  • Treatment over 3 days


  • Evaluated via counting the number of bacterium strains after treatment


  • The 7 profiles showed a significant decrease (p < 0.05) in the average intensities of fluorescence


  • The gel for skin susceptible to acne with 3% of active anti-adhesion bacteria causes a significant reduction ex vivo in the instance of Propionibacterium acnes in human perifollicular corneocytes
  • The inhibition of this measured ex vivo after 3 days of application of the gel ranged between 48% and 97% in the 7 subjects used in the trial