Shalita AR, Smith JG, Parish LC et al. Topical Nicotinamide Compared with Clindamycin Gel in the Treatment of Inflammatory Acne Vulgaris. Int. J Dermatology. 1995;34 (6): 434-437.
- Multicentre, double-blind, randomised active controlled study on topically applied 4% Nicotinamide gel versus 1% Clindamycin gel for the treatment of inflammatory acne vulgaris
- 76 patients, 38 patients in each treatment group
- One group treated with Nicotinamide gel 4%, the other with Clindamycin 1% gel, twice daily over 8 weeks
- Evaluated at weeks 4 and 8 using Physician’s Global Evaluation, Acne Lesion Counts and Acne Severity Rating
- After 8 weeks both treatment groups showed comparable beneficial results in the Physician’s Global Evaluation of inflammatory acne
- Both treatments produced statistically similar reductions in acne lesions and acne severity
- Nicotinamide 4% is as effective as Clindamycin 1% in the treatment of acne vulgaris